ANTI-INFLAMMATORY ACTIVITY OF SOME SUBSTITUTED HYDROXYTRIAZENES

Abstract

To study the anti-inflammatory activity of some substituted   hydroxytriazenes on carrageenan-induced hind paw edema and cotton pellet granuloma models in albino rats (Wister strain). The hind paw edema was produced by sub planter injection of carrageenan and the paw volume was measured plethysmographically after 0.5,1,2,3 & 5 hours. In sub-acute model, cotton pellet granuloma was produced by implanting 50 ± 1 mg sterile cotton in axilla under ether anesthesia. The animals were administered hydroxytriazenes (HD-1, HD-2, HD-3) dissolved in DMSO at dose (5 mg/kg) and diclofenac sodium (5 mg/kg), as standard drug.  All hydroxytriazenes showed maximum inhibition of edema up to 1 h. After 1 h the parent compound HD-1 did not show any significant activity, but the other hydroxytriazenes HD-2 and HD-3 showed significant activity up to 5 h.  In sub acute models, the hydroxytriazenes HD-2 and HD-3 exhibited significant activity by reducing the granuloma weights by 69.62% and 56.86% respectively Hydroxytriazenes (HD-2 and HD-3) show significant anti-inflammatory effect on both acute and sub acute inflammation.