COMPARISON OF OSTEOGENIC AND CHONDROGENIC DIFFERENTIATION POTENTIAL BETWEEN WHARTON’S JELLY AND ADIPOSE TISSUE MESENCHYMAL STEM CELLS AS THE ALTERNATIVES OF BONE MARROW MESENCHYMAL STEM CELLS: A SYSTEMATIC REVIEW
Abstract
Introduction. Currently, Bone Marrow is the most common source of Mesenchymal Stem Cell (MSC). The limitation of the source and pain post harvesting procedure make the next alternative of BM-MSC is needed. Wharton Jelly, offer a low cost and pain free collection method. Adipose tissue provide abundant amount stem cell and has a interestingly compatible osteogenic and chondrogenic activity. The objective of this study is to search alternative Bone Tissue Engineering (BTE) source other than BM-MSC.
Materials and Method. Literature search was conducted using several search engines. This review used all In vitro experimental comparison of Adipose Tissue Mesenchymal Stem Cells (AT-MSC) and wharton’s jelly stem cell (WJ-MSC). We compared osteogenic and chondrogenic differentiation potential between these MSCs. The group of comparison is divided into two sub groups, animal MSCs and human MSCs.
Result and Discussion. The first study that compared osteogenic and chondrogenic differentiation from animal AT-MSC and WJ-MSC consists of 7 trials. Most of the result shows that AT-MSC has greater osteogenic differentiation potential compared to WJ-MSC and controversial result for chondrogenic differentiation between them. The second study consist of 3 trials. In these studies, the results were more homogenous and concluded that AT-MSC has higher osteogenic differentiation potential than WJ-MSC but the chondrogenic differentiation were not significantly different.
Conclusion. AT-MSC may be more appropriate than WJ-MSC for osteogenesis and bone repair usage.
Keyword: Osteogenic differentiation, Chondrogenic differentiation, Wharton’s jelly Mesenchymal Stem Cells, Adipose Tissue Mesenchymal Stem Cells
Full Text:
PDFReferences
M. J. Barry FP, “Mesenchymal stem cells: Clinical applications and biological characterization,” Int J Biochem Cell Biol, vol. 36, no. 4, pp. 568–584, 2004.
S. Maher, E. Kolieb, N. A. Sabik, D. Abd-Elhalim, A. T. El-Serafi, and Y. El-Wazir, “Comparison of the osteogenic differentiation potential of mesenchymal cells isolated from human bone marrow, umbilical cord blood and placenta derived stem cells,” Beni-Suef Univ. J. Basic Appl. Sci., vol. 4, no. 1, pp. 80–85, 2015.
G. Brooke et al., “Points to consider in designing mesenchymal stem cell-based clinical trials,” Transfus. Med. Hemotherapy, vol. 35, no. 4, pp. 279–285, 2008.
A. Arthur, A. Zannettino, and S. Gronthos, “The therapeutic applications of multipotential mesenchymal/stromal stem cells in skeletal tissue repair,” J. Cell. Physiol., vol. 218, no. 2, pp. 237–245, 2009.
S. M. Drosse I, Volkmer E, Capanna R, De Biase P, Mutschler W, “Tissue engineering for bone defect healing: an update on a multi-component approach,” Injury, vol. 39, pp. S9–S20, 2008.
B. I. Woodbury D, Reynolds K, “Adult bone marrow stromal stem cells express germline, ectodermal, endodermal, and mesodermal genes prior to neurogenesis,” J Neurosci, vol. 69, pp. 908–917, 2002.
et al McGuckin C, Forraz N, Baradez M, Basford C, Dickinson A, Navran S, “Embryonic-like stem cells from umbilical cord blood and potential for neural modeling.,” Acta Neurobiol Exp, vol. 66, p. 321, 2006.
et al. Nishimori M, Yamada Y, Hoshi K, Akiyama Y, Hoshi Y, Morishima Y, “Health Related Quality of Life of Unrelated Bone Marrow Donors in Japan,” Blood, vol. 99, pp. 1995–2001, 2002.
“embryonic development and stem cel compendium,” life map discovery, 2011. [Online]. Available: https://discovery.lifemapsc.com/in-vivo-development/umbilical-cord/whartons-jelly.
O. C. et al A. Almaawi, H. T. Wang, “Effect of acetaminophen and nonsteroidal anti-inflammatory drugs on gene expression of mesenchymal stem cells,” Tissue Eng. A, vol. 19, no. 7–8, pp. 1039–1046, 2013.
A. M. A. et al O. Salem, H. Wang, “Naproxen affects osteogenesis of human mesenchymal stem cells via regulation of Indian hedgehog signaling molecules,” Arthritis Res. Ther., vol. 16, no. 4, p. 152, 2014.
E. J. et al I. Pountos, P. V. Giannoudis, “NSAIDS inhibit in vitro MSC chondrogenesis but not osteogenesis: implications for mechanism of bone formation inhibition in man,” J. Cell. Mol. Med., vol. 15, no. 3, pp. 525–534, 2011.
S. Undale, A.H., Westendorf, J.J., Yaszemski, M.J. & Khosla, “Mesenchymal Stem Cells for Bone Repair and Metabolic Bone Diseases,” Mayo Clin. Proc., vol. 84, pp. 893–902, 2009.
L. Chen, L., Song, J., Cui, J., Hou, J., Zheng, X., Li, C. & Liu, “microRNAs regulate adipocyte differentiation,” Cell Biol. Int., vol. 37, pp. 533–546, 2013.
K. Dai, R., Wang, Z., Samanipour, R., Koo, K.I. & Kim, “Adipose-Derived Stem Cells for Tissue Engineering and Regenerative Medicine Applications,” Stem Cells Int., 2016.
R. Fathi, E. & Farahzadi, “. Isolation, Culturing, Characterization and Aging of Adipose Tissuederived Mesenchymal Stem Cells: A Brief Overview.,” Brazilian Arch. Biol. Technofile///C/Users/asus/Desktop/Petrus/osteoblast chondroblast Form. Curitiba, vol. 59, 2016.
J. J. Sela and I. A. Bab, Principles of bone regeneration. 2012.
S. T. Hoynowski SM, Fry MM, Gardner BM, Leming MT, Tucker JR, Black L and M. KE, “: Characterization and differentiation of equine umbilical cord-derived matrix cells,” s. Biochem Biophys Res Commun, no. 362, pp. 347–353, 2007.
D. Barberini et al., “Equine mesenchymal stem cells from bone marrow, adipose tissue and umbilical cord: immunophenotypic characterization and differentiation potential,” Stem Cell Res. Ther., vol. 5, no. 1, p. 25, 2014.
L. F. Bartholomew S, Owens SD, Ferraro GL, Carrade DD, Lara DJ and G. L. Borjesson DL, “Collection of equine cord blood and placental tissues in 40 thoroughbred mares,” Equine Vet J, vol. 41, pp. 724–728, 2009.
W. M. Troyer DL, “Concise review: Wharton’s jelly-derived cells are a primitive stromal cell population,” Stem Cells, vol. 26, pp. 591–599, 2008.
M. B. Iacono E, Brunori L, Pirrone A, Pagliaro PP, Ricci F, Tazzari PL, “Isolation, characterization and differentiation of mesenchymal stem cells from amniotic fluid, umbilical cord blood and Wharton’s jelly in the horse,” Reproduction, no. 143, pp. 455–468, 2012.
B. Lovati AB, Corradetti B, Lange Consiglio A, Recordati C, Bonacina E and C. F. D, “Comparison of equine bone marrow-, umbilical cord matrix and amniotic fluid-derived progenitor cells,” Vet Res Commun, vol. 35, pp. 103–121, 2011.
J. Burk et al., “Growth and differentiation characteristics of equine mesenchymal stromal cells derived from different sources,” Vet. J., vol. 195, no. 1, pp. 98–106, 2013.
Toupadakis C.A., Woong A., Genetos D.C., Cheung W.K., Borjesson D.I., Ferraro G.L., Galuppo L.D., Leach J.K., Owens S.D., Yellowley C.E., “Comparison of the osteogenic potential of equine mesenchymal stem cells from bone marrow, adipose tissue, umbilical cord blood, and umbilical cord tissue,” Am. J. Vet. Res., vol. 71, pp. 1237–1245, 2010.
B. Kang et al., “Science Comparing the osteogenic potential of canine mesenchymal stem cells derived from adipose tissues , bone marrow , umbilical cord blood , and Wharton ’ s jelly for treating bone defects,” vol. 13, pp. 299–310, 2012.
B. D. Berg I, Koch T, Heerkens T, Bessonov K, Thomsen P, “Chondrogenic potential of mesenchymal stromal cells derived from equine bone marrow and umbilical cord blood,” Vet. Comp. Orthop. Traumatol., vol. 22, pp. 363–370, 2009.
N. D. Giovanni S, Brehm W, Mainil-Varlet P, “Multilineage differentiation potential of equine blood-derived fibroblast-like-cells,” Differentiation, vol. 76, pp. 118–129, 2008.
A. Zajdel, M. Kałucka, E. Kokoszka-mikołaj, and A. Wilczok, “Osteogenic differentiation of human mesenchymal stem cells from adipose tissue and Wharton ’ s jelly of the umbilical cord,” vol. 64, no. 2016, pp. 365–369, 2017.
M. M. Hoemann CD, El-Gabalawy H, “In vitro osteogenesis assays: influence of the primary cell source on alkaline phosphatase activity and mineralization.,” Pathol Biol, vol. 57, pp. 318–323, 2009.
G. C. Krause U, Seckinger A, “Assays of osteogenic differentiation by cultured human mesenchymal stem cells,” Methods Mol Biol, no. 698, pp. 215–230, 2011.
Á. Szepesi et al., “In Vitro Characterization of Human Mesenchymal Stem Cells Isolated from Different Tissues with a Potential to Promote Complex Bone Regeneration,” vol. 2016, p. 9, 2016.
J. Y. S.Yu,J.Long, ““Analysisofdifferentiationpotentials andgeneexpressionprofilesofmesenchymalstemcellsderived fromperiodontalligamentandwharton’sjellyoftheumbilical cord,” CellsTissuesOrgans, vol. 197, pp. 209–223, 2013.
P. Amable, M. V. Teixeira, R. B. Carias, J. Granjeiro, and R. Borojevic, “Protein synthesis and secretion in human mesenchymal cells derived from bone marrow, adipose tissue and Wharton’s jelly,” Stem Cell Res. Ther., vol. 5, no. 2, p. 53, 2014.
Refbacks
- There are currently no refbacks.
