Design and Development of Losartan Potassium Press Coated Tablets for Pulsatile Drug Delivery

S Ramkanth, Ashok Kumar Janakiraman, Saminathan Kayarohanam, Vetriselvan Subramaniyan, Sinouvassane Djearamane


The objective of the present study was to design and evaluate time-dependent pulsatile delivery systems (PDDS) of losartan potassium pulsatile press coated tablets. Losartan potassium (LP) is angiotensin II (AG II) receptor antagonists to treat hypertension. LP pulsatile systems are time-controlled drug delivery systems which are designed to mimic the circadian rhythm of the body and deliver the drug at a specific time. LP core tablets were prepared by direct compression method using a single punch machine. The prepared tablets were shielded with a combination of different grades of Hydrosy propyl methyl cellulose (HPMC) and Ethyl cellulose (EC) as coated materials. Prepared core and pulsatile tablets were optimized and evaluated for various properties like diameter and thickness, uniformity of weight, hardness, friability, disintegration time, drug content and in vitro dissolution studies. The drug release profile LP pulsatile tablet batch of LH-3 designated as the optimized batch that shows the lag time 8 hrs with complete drug release of 99%. LP pulsatile tablets will be taken at bedtime, releasing the drug in the morning hrs when the symptoms are more prevalent can prove to be a revolution in the treatment of hypertension.

Full Text:



Lamberg L. Chronotherapeutics: Implications for drug therapy. American Pharmacy 1991; 31(11): 20-23.

Pawar A, Sharma S. Low density multiparticulate system for pulsatile release of meloxicam. Int J Pharm. 2006; 313: 150–58.

Bussemer T, Otto I,Bodmeier R. Pulsatile drug delivery systems. Crit Rev Ther Drug Carrier Syst. 2001; 18(5): 433-58.

Belgamwar V.S, M.V. Gaikwad, G.B. Patil, S. Surana. Pulsatile drug delivery system, Asian J. Pharm. 2008; 2(3): 141–145.

Patel V.R, V.P. Patel. Pulsatile drug delivery system - A review. Int. J. Pharm. Sci. Res. 2015; 6: 3676–3688.

Youan B.C. Chronopharmaceutics: gimmick or clinically relevant approach to drug delivery, J. Control. Release 2004; 98: 337–353.

Prasanth V.V, Modi MP, Mathew ST. Pulsatile: a tool for circardian rhythm – a review. J. Drug Deliv. Ther. 2012; 2: 58–65.

Ashwini M.S,Mohammed Gulzar Ahmed. Design and Evaluation of Pulsatile Drug Delivery of Losartan Potassium. Dhaka Univ. J. Pharm. Sci. 2013; 12(2): 119-123.

Nagaraja G, Sunil Agarwal, Dinesh Shenoy, Paramjeet Singh Minhas, Yogesh D. B,Fazil Baig. Design and evaluation of time programmed pulsincap system for chronotherapeutic delivery of losartan potassium. J. Chem. Pharm. Res. 2013; 5(6): 76-87

Deveswaran R, S. Bharath, S. Furtado, B.V. Basavaraj, S. Abraham and V. Madhavan. Studies on the Disintegrant properties of Mucilage and Seed Powder of Plantagoovata. International Journal of ChemTech Research. 2009; 1: 621-626.

Shirsand S, S. Suresh, M. Para, P. Swamy and D. N. Kumar. Plantagoovata mucilage in the design of fast disintegrating tablets. Indian Journal of Pharmaceutical Science 2009; 71: 41-45.

Bajpai M, D. C. P. Singh, A. Bhattacharya, A. Singh. Design and In Vitro Evaluation of Compression-coated Pulsatile Release Tablets of Losartan Potassium. Indian J Pharm Sci. 2012; 74(2): 101–106.

Amanda Ng, Ashok Kumar J, Liew KB, Melbha S, Habibur Rahman. The effects of the combination of biodegradable and synthetic polymers on the release behaviour of Nateglinide matrix tablets. J. Excipients and Food Chem. 2019; 10 (1): 13-22.

Rishabha Malviya, Pranati Srivastava. Preparation, Characterization and Application of Chitosan– Alginate Based Polyelectrolyte Complex as Fast Disintegrating Drug Delivery Carrier. Polimery w Medycynie 2011; 41(3): 45-54.

Ebere I. Okoye, Titilope O. Awotunde, Tessy G. Morales. Formulation and Characterization of Moringa oleifera Leaf Granules. I: Micromeritic Properties. Research J. Pharm. and Tech. 2013; 6(1): 66-74.

Chowdary K. P. R, K. V. N. R. Aishwarya, Preparation and evaluation of fast dissolving tablets of Paracetamol employing superdisintegrants. Journal of Global Trends in Pharmaceutical Sciences; 2013; 4 (4): 1329-1335

Sateesh K. Vemula,Santhosh G. Reddy. Formulation and Pharmacokinetics of Flurbiprofen Sublimated Fast Dissolving Tablets. Open Pharmaceutical Sciences Journal, 2015; 2: 56-65

Chiranjibi Adhikari, Gururaj S Kulkarni, Shivakumar Swamy. Formulation and evaluation of pulsatile drug delivery system of Salbutamol sulfate for the chronotherapy of asthma. Asian J Pharm Clin Res, 2018; 11(9): 305-311.

Adel Penhasia, Mila Gomberg. Design and development of an innovative water insoluble film-coating combination for oral pulsatile drug delivery. Journal of Drug Delivery Science and Technology 2018; 43: 274–282.

Manish Kumar Gupta, Swarnlata Saraf. Formulation and Evaluation of Pulsatile Drug Delivery System of Ramipril for Controlling Morning Spate of B.P. Journal of Pharmaceutical Research, 2018; 17(1): 1-11.

Syeda Nausheen Fatima, Shahid Mohammed. Formulation and invitro evaluation of meloxicam Pulsin cap for pulsatile drug delivery. International Journal of Innovative Pharmaceutical Sciences and Research 2017; 5 (8):126-138.

Sadaf Muzaffar, Syed Abdul Azeez Basha, Umm-E-Hani, Mohd Munawar Ali Tauqeer. Formulation and evaluation of pulsatile drug delivery system using meloxicam. Int. J. of Pharmacy and Analytical Research. 2015; 4(1): 51-59.


  • There are currently no refbacks.