Formulation and Evaluation of Oral Disintegrating Film Containing Lisinopril for the Effective Management of Hypertension and Cardiac Diseases

Velayutham Pazhanivel

Abstract

This study was aimed to develop oral disintegrating film (ODF) containing an anti-hypertensive drug Lisinopril. Five trial formulations (F1-F5) of Lisinopril ODF were prepared using Hydroxypropyl methylcellulose E15 (HPMCE15), Polyvinyl pyrrolidone (PVPK30), Polyethyleneglycol400, Polyplasdonexl, Mannitol, Peppermint oil, Propylparaben, Citric acid, and Allura red. The prepared formulations were evaluated for their Physico-chemical characters like weight, thickness, surface pH, folding endurance, and disintegration time. They were also evaluated for the content of Lisinopril. The above studies revealed that formulations trial F4 was better than other Formulations. Because, it has exhibited faster disintegration time (21.32 sec) when compared to the other formulation. So, F4 was selected for stability study (40ᵒC,75% RH) for six months and Scanning Electron Microscopy (SEM). The results of the above studies have shown that F4 was stable and has a uniform distribution of Lisinopril.

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References

TM-A, Improvement ON, Patient OF, Paediatrics FOR. International Journal of Institutional. 2015;5(June):411-428.

Bhyan B, Jangra S, Kaur M, Singh H. Orally fast dissolving films: Innovations in formulation and technology. Int J Pharm Sci Rev Res. 2011;9(2):50-57.

Arya A, Chandra A, Sharma V, Pathak K. Fast dissolving oral films: An innovative drug delivery system and dosage form. Int J ChemTech Res. 2010;2(1):576-583.

Patel AR, Prajapati DS, Raval JA. Fast dissolving films (FDFs) as a newer venture in fast-dissolving dosage forms. Int J Drug Dev Res. 2010;2(2):232-246.

Scarpa M, Stegemann S, Hsiao WK, et al. Orodispersible films: Towards drug delivery in special populations. Int J Pharm. 2017;523(1):327-335 DOI:10.1016/ j.ijpharm.2017.03.0181.

Challan N, Maheshwari RK, Carpenter G. Formulation and development of fast dissolving oral film of poorly soluble drug piroxicam with improved drug loading using mixed solvency concept and its evaluation. Asian J Pharm. 2018;12(3): S907-S915. DOI:10.22270/ jddt. V 8i6.2034

Patil PC, Shrivastava SK, S. V, P. A. Oral Fast Dissolving Drug Delivery System: a Modern Approach for Patient Compliance. Int J Drug Regul Aff. 2018;2(2):49-60. DOI:10.22270/ idea. V 2i2.1311.

Plants M, Anti W, Activity C. International Journal of Universal. 2013;2(June):285-297.

Pande V V., Patel AA, Patel VP, Khedkar P V. Formulation and evaluation of fast dissolving film of fosinopril. Indian Drugs. 2018;55(12):34-40. DOI:10.4103/16874315.154723.

Lisinopril. The American Society of Health-system Pharmacists. Available at: http://www.drugs.com/monograph/lisinopril.html.

Chowdary Y., M S, M MB, KA, P H. A Review on Fast Dissolving Drug Delivery Systems- A Pioneering Drug Delivery Technology. Indian J Nov Drug Deliv. 2012;4(4):252-263.

Mahajan A, Chhabra N, Aggarwal G. Formulation and characterization of fast dissolving buccal films: A review. Der Pharm Lett. 2011;3(1):152-165.

Patil BS, Raghavendra Rao NG. Formulation and evaluation of fast dissolving tablets of granisetron hydrochloride by vacuum drying technique. J Appl Pharm Sci. 2011;1(4):8388.

Nalluri BN, Sravani B, Maheswari KM, Srianusha VS, Bramhini RS. Journal of Chemical and Pharmaceutical Research, 2013, (3): 53-60 Research Article Development and evaluation of mouth dissolving films of salbutamol sulfate. 2013;5(3):53-60.

MS A, C V. Formulation and Evaluation of Fast Dissolving Oral Films of Diazepam. J Pharmacovigil. 2016;4(3). DOI:10.4172/2329-6887.10002101.

Zuberi MH, Ahmed F. Chemistry Simultaneous determination of metformin, captopril, lisinopril, and enalapril by RP-HPLC: its applications in dosage formulations and human serum. 2013. DOI:10.1007/s00044-013-0501-z1.

Arayne MS, Sultana N. RP-HPLC Method for the Determination of Lisinopril in Active Pharmaceutical Ingredients, Dosage Forms, and Human Serum. 2013;(November):3-8. DOI:10.4172/scientificreports.81.

Raju VB, Rao AL. Development, Estimation, and Validation of Lisinopril in Bulk and its Pharmaceutical Formulation by HPLC Method. 2012;9(1):340-344.

Taylor P, Chander V, Mohan M, Seth R, Singh P, Singh R. Development and Validation of RP-HPLC Method for the Estimation of Lisinopril in Tablet Dosage Form. 2012;(April 2015):37-41. DOI:10.1080/22297928.2012.106482821.

Imam SS, Ahad A, Aqil M, Sultana Y, Ali A. Original Article determination of propranolol and valsartan in bulk drug and gel formulation. 2013;5(1):61-65. DOI:10.4103/09757406.106573.

Sastry BS, Gananadhamu S, Devadasu C, Balaji K. New Rp-HPLC Method for Estimation of Donepezil Hydrochloride in Pharmaceutical Formulations. Int J Chem Sci. 2008;6(4):1976-1983.

Ketul P, Patel KR, Patel, MR, Patel NM. Asian Journal of Pharmaceutical Science & Technology fast dissolving films: a novel approach to oral drug delivery. 2013;3(1):25-31.

Viny Umesh Rao M Sudhakar, K. Kishore Kumar PSS. Development and Optimization of Orally Dissolving Film of Zolpidem Tartrate. Am J Adv Drug Deliv. 2013;1(3):251-261.

Japanese pharmacopeia 15. General tests, processes, and apparatus. Tokyo, Japan: The society of Japanese pharmacopoeia.p.107.

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