Long Term Use of Ovarian Stimulation Drugs May Affect Thyroid Function

Abstract

Background: The use of ovarian stimulation drugs has increased worldwide; this is associated with physiological and biochemical alteration in different body systems. This study aims to evaluate the impact of different types of ovarian stimulation programs on thyroid hormone levels through different time exposure. Methods: Eighty women were involved in this study. Twenty women were considered as a control group (volunteers with no history of any health problems). The rest show no sign or symptom for thyroid impairment, they were divided into three groups, Group (A) contain twenty women treated with Clomid only, group (B) another twenty women treated with pergonal only, and the last twenty women group (C) were treated with both Clomid and pergonal (Mix). Measurement of TSH, T3, and T4 concentration before and after administration of different ovarian stimulation drugs and for a different time exposure. Results: This study proved a variation in thyroid hormone level during different time exposure and with different drugs used, some of them show no significant difference in the levels of thyroid hormones for two month after administration (group A) as compared to the control group, while in group (C) the increased of TSH hormone was significant (P<0.05) from the first month, as well as the decrement in T3 and T4 (P<0.05) as compared to control.. Conclusions: The current study showed a strong relationship between controlled ovarian hyperstimulation and thyroid function.
Keywords: Ovarian stimulation drugs, Thyroid hormones, Thyroid disorder.