Synthesis, Structural Study and Biological Activity Evaluation of Cr (III), Mn (II), Zn (II), Cd (II) and Hg (II) Complexes with New Schiff Base Ligand Derived from Isatin

Abstract

The New Schiff base [3E-3-((1,5-dimethyl-3-((4-nitrophenyl)imino)-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)imino)indolin-2-one][L] was prepared by two steps, 4-aminoantipyrine was reacted with isatin in the first step to produce the precursor [A], then [A] was reacted with p-nitroaniline to give a new tridentate ligand [L]. this ligand[L] was reacted with some metal ions in Cr (III), Mn(II), Zn(II), Cd(II) and Hg(II)to give a series of new metal compexes of the general molecular formula [M(L)2]Cln , where: M=Cr(III), n=3; M=Mn(II),Zn(II),Cd(II) and Hg(II), n=2. All compounds were have been characterized by spectroscopic methods [ IR, UV-Vis, atomic absorption],elemental microanalysis, chloride content, magnetic susceptibility, conductivity measurements along with 1H,13C-NMR and mass spectroscopy for ligand [L] only. According to the results of the above techniques, the suggested geometrical structures for all prepared complexes were octahedral formula.

Keywords: Schiff base, Isatin, 4- amino antipyrine.